FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and pharmaceutical industry, and concerns a controlled release drug exceeding an active ingredient in stability. The drug may show pharmacological effects stably and immediately after the introduction, and provides a prolonged pharmacological effect for a long period of time.
EFFECT: controlled release solid drug contains a combination of (1) antacid, (2) an immediate release portion containing an acid and base unstable compound, and (3) a prolonged release portion containing an acid and base unstable compound, and having a film which is dissolved at pH 6,5 and higher.
14 cl, 12 ex, 8 tbl
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