NIACIN-CONTAINING PHARMACEUTICAL COMPOSITION (VERSIONS) AND TABLET PREPARATION, METHOD FOR REDUCING HYPEREMIA AND METHOD FOR PREPARING NIACIN-CONTAINING TABLET Russian patent published in 2012 - IPC A61K31/455 A61K47/38 A61K47/32 A61K47/12 A61K9/30 A61J3/10 A61P3/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a pharmaceutical composition containing niacin 1000 mg. The composition contains 78 to 82 wt % of granulated niacin, with 85 wt % of granulated niacin having a particle size within the range of 100 to 425 mcm and no more than 10 wt % of granulated niacin having a particle size less than 100 mcm. Also, the composition contains 14 to 18 wt % of hydroxypropyl methyl cellulose of a methoxy substitution degree within the range of 1.39 to 1.41 and hydroxyl propoxyl molar substitution within the range of 0.20 to 0.22, 2.5 to 3.0 wt % of polyvinylpyrrolidone and 0.5 to 1.5 wt % of stearic acid. What is also described is a method for preparing said niacin tablet and a method for reducing hyperemia.

EFFECT: tablets under the present invention show favourable characteristics of release, reduction of severity, length and number of cases of skin hyperemia, generally caused by niacin therapy.

24 cl, 27 dwg, 30 tbl, 8 ex