FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed are: a peroral pharmaceutical composition with an instant release for treating pain in patients or for titration of a dose for the patients, suffering from pain, which contains at least oxicodon or its pharmaceutically acceptable salt and naloxon or its pharmaceutically acceptable salt in an approximate weight ratio oxicodon or its pharmaceutically acceptable salt: naloxon or its pharmaceutically acceptable salt 2:1 (versions), its application for obtaining medication for titration of the dose for the patients, suffering from pain, its application for obtaining medication for treatment of breakthrough pain, a method of titration of the dose in the patient, suffering from pain, and a method of treating breakthrough pain.
EFFECT: achievement of the claimed results with absence of undesirable side effects of opioid is demonstrated, with levels of naloxon in the blood plasma being extremely low, bioavailability of oxicodon constituting 96.3 or 99.2%, and tablets being stable in storage.
30 cl, 9 dwg, 15 tbl
