HYDROSULFIDE DERIVATIVES OF NON-STEROID ANTI-INFLAMMATORY DRUGS Russian patent published in 2012 - IPC C07D339/04 C07D209/28 C07C327/48 C07C331/28 A61K31/385 A61P29/00

Abstract RU 2468019 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to derivatives of non-steroid anti-inflammatory drugs (NSAID) of general formula: A-Y-X (Formula I), where A represents NSAID radical, selected from group, consisting of acetylsalicylic acid (ASA), diclofenac, naproxen, indomethacin, flurbiprofen, ibuprofen, ketoprofen and lumoracoxib, Y represents -C(O)O-, and X is selected from group, consisting of: and , which have improved anti-inflammatory properties, suitable for treatment of inflammation, pain and fever.

EFFECT: obtained are NSAID derivatives with hydrosulfide (H₂S)-releasing fragment, for obtaining novel anti-inflammatory compounds, which have weakened side effects.

23 cl, 16 dwg, 24 ex

Similar patents RU2468019C2

Title	Year	Author	Number
4-HYDROXYBENZAMIDE DRUG DERIVATIVES	2007	Uollehjs Dzhon L. Chirino Dzhuzeppe Santagada Vinchentso Kal'Endo Dzhuzeppe	RU2465271C2
4- OR 5-AMINOSALICYLIC ACID DERIVATIVES	2006	Uollehjs Dzhon L. Chirino Dzhuzeppe Kalendo Dzhuzeppe Sparatore Anna Santagada Vinchentso F'Oruchchi Stefano	RU2414476C2
NITROESTERS EXHIBITING ANTI-INFLAMMATORY AND/OR ANALGETIC ACTIVITY, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS	1994	Del Soldato P'Ero	RU2136653C1
DERIVATIVE OF HYALURONIC ACID AND MEDICAL AGENT THAT CONTAINS IT	2005	Mijamoto Kendzi Jasuda Jousuke Josioka Kejdzi	RU2390529C2
ANETHOLDITHIOLTHIONES AND OTHER DITHIOLTHIONES FOR TREATING CONDITIONS ASSOCIATED WITH MONOAMINE NEUROTRANSMISSION DYSFUNCTION	2006	Drjukarkh Bendzhamin Skhoffelmer Anton N.M. Fenstra Rulof V. Kristen Mari-Odil' Bjurgo Zhan-Lui Sholle Marilen Ivema Bakker Vauter I. Van Vliet Bernard J. Tjulp Martinus T.M.	RU2402543C2
AMIDINES AND THEIR DERIVATIVE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF	2004	Allegretti Marchello Chesta Marija Kandida Nano Dzhuzeppe Bertini Rikkardo Bitstsarri Tsintsija Kolotta Franchesko	RU2375346C2
NITROXYCOMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING ANTI-INFLAMMATORY, ANALGETIC AND ANTITHROMBOCYTIC ACTIVITY	1995	Del Soldato P'Erro Sannikolo Franchesko	RU2145595C1
PHARMACEUTICAL COMPOSITION, INCLUDING TRICYCLIC SULFUR-CONTAINING 1,2-DIHYDROQUINOLINE DERIVATIVE FOR INHIBITION OF REPLICATION OF BETA CORONAVIRUSES, INCLUDING SARS-CoV-2, AND METHOD OF ITS USE	2021	Shikhaliev Khidmet Safarovich Medvedeva Svetlana Mikhajlovna Zorina Anna Vyacheslavovna Stolpovskaya Nadezhda Vladimirovna Sulimov Vladimir Borisovich Sulimov Aleksej Vladimirovich Kutov Danil Konstantinovich Pyankov Oleg Viktorovich Shcherbakov Dmitrij Nikolaevich	RU2814434C1
METHOD OF PRODUCING 2,2-DIALKYL-4,5-DIARYLFURAN-3(2H)-ONES	2014	Medvedev Jurij Jur'Evich Semenok Dmitrij Vladimirovich Nikolaev Valerij Aleksandrovich Rodina Ljudmila Leonidovna	RU2563876C1
METHOD OF PRODUCING A TRICYCLIC SULFUR-CONTAINING DERIVATIVE OF 1,2-DIHYDROQUINOLINE FOR INHIBITING REPLICATION OF BETA-CORONAVIRUSES, INCLUDING SARS-CoV-2	2021	Shikhaliev Khidmet Safarovich Medvedeva Svetlana Mikhajlovna Zorina Anna Vyacheslavovna Stolpovskaya Nadezhda Vladimirovna Sulimov Vladimir Borisovich Sulimov Aleksej Vladimirovich Kutov Danil Konstantinovich Pyankov Oleg Viktorovich Shcherbakov Dmitrij Nikolaevich	RU2819783C1

RU 2 468 019 C2

Authors

Uollehjs Dzhon L.

Chirino Dzhuzeppe

Santagada Vinchentso

Kalendo Dzhuzeppe

Dates

2012-11-27—Published

2007-07-18—Filed