METHOD OF PRODUCING 2,2-DIALKYL-4,5-DIARYLFURAN-3(2H)-ONES Russian patent published in 2015 - IPC C07D307/58 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel method of producing 2,2-dialkyl-4,5-diarylfuran-3(2H)-ones of general formula 1 , where Alk and Alk¹=CH₃, CH₃CH₂ or other alkyl or cycloalkyl groups, and Ar and Ar¹=Ph, p-X-C₆H₄ (X=H, MeO, MeS, MeSO, MeSO₂, Hal) and other substituted or unsubstituted aryl groups, the method comprising six-step synthesis based on reaction of 1,1-dialkylprop-2-yn-1-ols and substituted benzophenone, which results in the desired 2,2-dialkyl-4,5-diarylfuran-3(2H)-ones, and comprising as the key step 1,2-nucleophilic rearrangement of 4-diazo-2,2-dialkyl-5,5-diaryldihydrofuran-3(2H)-ones, catalysed by an organic or inorganic acid. Obtained compounds exhibit cyclooxygenase-2 enzyme selective inhibitor properties and can be used as non-steroid anti-inflammatory preparations for a long therapy of joints diseases.

EFFECT: simple process and high output of the end product.

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