G-PROTEIN-CONJUGATED RECEPTOR WHICH HAVING ALTERED LIGAND AFFINITY AND APPLICATION THEREOF Russian patent published in 2012 - IPC C07K14/47 C07K17/02 C07K19/00 C12N1/15 C12N1/19 C12N1/21 C12N5/10 C12N15/09 G01N33/15 G01N33/50 C07K14/705

Abstract RU 2468035 C2

FIELD: medicine.

SUBSTANCE: obtained is protein complex, possessing GPCRα_1L affinity to ligand, which includes GPCRα_1A and polypeptide with sequence of amino acids SEQ ID NO:1. Binding of said G-protein-conjugated receptor with polypeptide alters ligand affinity of the receptor. Also claimed are methods of screening agonists or antagonists of G-protein-conjugated receptor with application of transformant, in which said altered G-protein-conjugated receptor is expressed.

EFFECT: carrying out analysis of many supposed G-protein-conjugated receptors with still unknown structure.

12 cl, 3 dwg, 2 tbl, 4 ex

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RU 2 468 035 C2

Authors

Muramatsu Ikunobu

Dates

2012-11-27—Published

2008-05-22—Filed