(3R,4R,5S)-4-ACYLAMINO-5-AMINO-3-(1-ETHYL-PROPOXY)-CYCLOHEX-1-ENE-CARBOXYLIC ACIDS, THEIR ESTERS AND METHOD FOR USING Russian patent published in 2012 - IPC C07C233/63 C07C237/02 C07C275/26 A61K31/17 A61K31/196 A61K31/21 A61P31/16 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new substituted (3R,4R,5S)-5-amino-4-acylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene carboxylic acids of general formula 1, their esters, pharmaceutically acceptable salts and/or hydrates possessing antiviral activity associated with inhibition of neuraminidase, particularly influenza virus neuraminidase. The invention also refers to pharmaceutical compositions and a based drug preparation, a method for inhibition of neuraminidase, and a method of treating influenza and pneumonia caused by influenza virus. In general formula 1 R1 represents hydrogen, C₁-C₇alkyl, C₂-C₇alkenyl or C₂-C₇alkinyl optionally substituted by C₃-C₆cycloalkyl, phenyl, pyridyl, C₁-C₃alkoxy; R2 represents hydrogen; -NH₂; C₂H₅O-, substituted C₁-C₅alkyl specified in -CH₂OH, -CH₂-NH₂, -CH=CH₂, -CH=CHCl, -C=CH, -CH₂F, -CHF₂, -CF₃, -CH₂CF₃, cyclo-C₃H₇, -CF₂CF₂CF₂CF₃, -CF₂CF₂CF₂CHF₂, -CH₂CF₂CF₂CF₂CF₃.

EFFECT: compounds can find application in treating influenza virus and pneumonia caused by influenza virus.

10 cl, 3 tbl, 33 ex