FLUORINE-SUBSTITUTED (3R,4R,5S)-5-GUANIDINO-4-ACYLAMINO-3-(PENTAN-3-YLOXY)CYCLOHEXENE-1-CARBOXYLIC ACIDS, ESTERS THEREOF AND METHOD OF APPLICATION Russian patent published in 2013 - IPC C07C279/16 A61K31/155 A61P31/16 

FIELD: chemistry.

SUBSTANCE: invention relates to novel neuraminidase inhibitors and use thereof in preventing and treating influenza infection, and specifically to novel fluorine-substituted 4-acylamino-5-guanidino-3-(pentan-3-yloxy)cyclohexene-1-carboxylic acids, esters thereof of general formula 1 and pharmaceutically acceptable salts and/or hydrates thereof. In formula R is hydrogen, C₁-C₅alkyl, C₂-C₅alkenyl or C₂-C₅alkynyl, optionally substituted with C₃-C₆cycloalkyl, phenyl, pyridyl, C₁-C₃alkoxy; Rf is CH₂F or CHF₂. The invention also relates to a pharmaceutical composition, a method of inhibiting neuraminidase, particularly neuraminidase of the influenza virus and a method of preventing and treating influenza and viral diseases caused by the influenza virus such as pneumonia.

EFFECT: high efficiency of using said compounds.

10 cl