FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing (13C2-carbonyl)dimethyl phthalate which can be used to produce (13C2-carboxy)phthalic acid. Both compounds can be used to produce a range of agents for tumour diagnosis and therapy. The disclosed method involves carbonylation of 1,2-dibromobenzene with carbon monoxide 13CO in methanol at temperature of 100-150°C, pressure of not more than 1.0 MPa, in the presence of a catalyst system containing palladium acetate and a phosphine ligand, taken in molar ratio of 1:0.5-1:10, in the presence of triethylamine or sodium acetate. The method enables to obtain a product with output of up to 94.5% with isotopic purity of up to 99.3%. Catalyst efficiency reaches 9.9 mol/mol-h. (13C2-carboxy)phthalic acid with isotopic purity of 99% can be obtained from the obtained product via acid hydrolysis.
EFFECT: high output of the end product.
2 cl, 5 ex
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