2-(2-OXOINDOLIN-3-YLIDENE)METHYL-5-(2-HYDROXY-3-MORPHOLIN-4-YLPROPYL)-6,7-DIHYDRO-1-H-PYRROLE[3,2-C]PYRIDIN-4(5H)-ONE COMPOUNDS AND USE THEREOF AS PROTEIN KINASE INHIBITORS Russian patent published in 2013 - IPC C07D417/04 C07D209/30 C07D209/04 A61K31/437 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salts thereof: where: each of R₁, R₂, R₃, R₄ is independently selected from a group consisting of a hydrogen atom, a halogen atom, an aryl, a C_5-6 heteroaryl having 1-3 heteroatoms in the ring which are selected from O, S and N, -OR₅, -NR₅R₆, and -NR₅COR₆, where said aryl or C_5-6 heteroaryl, having 1-3 heteroatoms in the ring selected from O, S and N, is unsubstituted or additionally substituted with one or more groups selected from a group consisting of alkyl, alkoxyl and halogen, each of R₅ and R₆ is independently selected from a group consisting of a hydrogen atom or an alkyl, where said alkyl is unsubstituted or additionally substituted with one or more groups selected from a group consisting of an aryl, haloaryl, hydroxyl and alkoxyl. The invention also relates to a pharmaceutical composition which inhibits protein kinase and contains a compound of formula I, a method of producing the compound of formula I, use of said compounds to produce a medicinal agent for treating disorders associated with protein kinase, and a method of modulating catalytic activity of protein kinase.

EFFECT: improved method.

10 cl, 24 ex