HETEROCYCLIC NITROGEN PYRROLE DERIVATIVES, PRODUCING THEM AND PHARMACEUTICAL APPLICATION Russian patent published in 2013 - IPC C07D209/34 C07D519/00 C07D487/04 C07D471/04 A61K31/404 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new pyrrole nitrogen-containing heterocyclic derivatives of formula (I) or their pharmaceutically acceptable salts:

,

wherein: X means C, N; each R₁,R₂ means H; R₃ means C_1-10alkyl; R₄ means -[CH₂CH(OH)]_rCH₂NR₉R₁₀, -(CH₂)_nNR₉R₁₀; provided X means N, R₅ is absent, each R₆, R₇, R₈ means H, halogen; provided X means C, each R₅, R₆, R₇, R₈ means H, halogen, hydroxyC_1-10alkyl, C_1-10alkyl, phenyl, 6-member heteroaryl with one N, -OH, -OR₉, -NR₉R₁₀, -(CH₂)_nCONR₉R₁₀, -NR₉COR₁₀, -SO₂R₉ and -NHCO₂R₁₀, wherein said phenyl is unsubstituted or additionally substituted by one or more group C_1-10alkyl, C_1-10alkoxyl, halogen; each R₉, R₁₀ means H, C_1-10alkyl wherein C_1-10alkyl is unsubstituted or additionally substituted by one or more group C_1-10alkyl, phenyl, halogenophenyl, -OH, C_1-10alkoxy, OH- C_1-10alkyl; or R₉ and R₁₀ together with an attached atom form a 5-6-member heteroring which may contain one O; n is equal to 2- 6; z is equal to 1-2; r is equal to 1-6;.

EFFECT: compounds may be used as protein kinase inhibitors.

14 cl, 2 tbl, 67 ex