DERIVATIVES OF 6-AMINO QUINAZOLINE OR 3-CYANOQUINOLINE, METHODS OF THEIR PRODUCTION AND THEIR APPLICATION AS INHIBITORS OF RECEPTOR TYROZINE KINASES EGFR OR HER-2 Russian patent published in 2014 - IPC C07D401/12 C07D401/14 C07D403/12 C07D403/14 C07F9/6558 A61K31/4709 A61K31/517 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to field of organic chemistry, namely to heterocyclic compound of formula (I) or its racemate, enantiomer, diastereoisomer and their mixture, as well as to their pharmaceutically acceptable salt, where A is selected from the group, consisting of carbon atom or nitrogen atom; when A represents carbon atom, R¹ represents C₁-C₆-alkoxyl; R² represents cyano; when A represents nitrogen atom, R¹ hydrogen atom or C₁-C₆-alkoxyl; where said C₁-C₆-alkoxyl is optionally additionally substituted with one C₁-C₆-alkoxyl group; R² is absent; R³ represents radical, which has the formula given below: or , where D represents phenyl, where phenyl is optionally additionally substituted with one or two halogen atoms; T represents -O(CH₂)_r-; L represents pyridyl; R⁴ and R⁵ each represents hydrogen atom; R⁶ and R⁷ each is independently selected from hydrogen atom or hydroxyl; R⁸ represents hydrogen atom; R⁹ represents hydrogen atom or C₁-C₆-alkyl; r equals 1 and n equals 2 or 3. Invention also relates to intermediate compound of formula (IA), method of obtaining compound of formulae (I) and (IA), pharmaceutical composition based on formula (I) compound and method of its obtaining and to application of formula (I) compound.

EFFECT: novel heterocyclic compounds, inhibiting activity with respect to receptor tyrosine kinases EGFR or receptor tyrosine kinases HER-2 are obtained.

18 cl, 12 ex, 4 tbl