METHOD OF PRODUCING 16α,17α-CYCLOHEX-3',4'-ENOPREGN-5-EN-3β-OL-20-ONE ACETATE Russian patent published in 2013 - IPC C07J53/00 

FIELD: chemistry.

SUBSTANCE: task is achieved by the disclosed method of producing 16α, 17α-cyclohex-3',4'-enopregn-5-en-3β-ol-20-one acetate by reacting 16-dehydropregnenolone acetate with 1,3-butadiene in the medium of an organic solvent in the presence of a Lewis acid, characterised by conducting the process in molar ratio 16-dehydropregnenolone acetate: 1,3-butadiene: Lewis acid equal to 1:2-3:0.2-0.4 at temperature of -10°C, and then raising temperature of the reaction mixture to room temperature, passing the reaction mixture through a sorbent layer and separating the end product using existing methods.

EFFECT: simple method of producing an intermediate product in synthesis of steroid hormones of the pregnane family by not conducting the process in a sealed apparatus.

3 cl, 6 ex