FIELD: chemistry.
SUBSTANCE: goal is achieved using the described method of producing 16α,17α-cyclohex-3',4,-enopregn-5-en-3β-ol-20-one acetate by reacting 16-dehydropregnenolone with 1,3-butadiene in the medium of an organic solvent - toluene, at temperature of -10°C n the presence of a Lewis acid and treating the reaction mixture with a solution of soda and water, followed by separation of the end product using existing methods.
EFFECT: simple method of producing an intermediate product in synthesis of pregnane steroid hormones by not conducting the process in a sealed apparatus.
1 cl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 16α,17α-CYCLOHEX-3',4'-ENOPREGN-5-EN-3β-OL-20-ONE ACETATE | 2011 |
|
RU2472802C1 |
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RU2480477C1 |
| METHOD OF PRODUCING 16α, 17α-CYCLOHEXANOPREGN-5-EN-3β-OL-20-ONE ACETATE | 2012 |
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RU2495047C1 |
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| BRIDGE-CONTAINING ESTRATRIENES | 1990 |
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