METHOD OF PRODUCING 16α,17α-CYCLOHEXANO-5α,6α-EPOXYPREGN-3β-OL-20-ONE ACETATE Russian patent published in 2013 - IPC C07J53/00

Abstract RU 2480477 C1

FIELD: chemistry.

SUBSTANCE: method of producing 16α,17α-cyclohexano-5,6-epoxypregn-3β-ol-20-one acetate involves treatment of 16α,17α-cyclohexanopregn-5-en-3β-ol-20-one acetate with p-carbomethoxyperbenzoic acid in a medium of polar methylene chloride and the process is carried out at temperature of 25-30°C and molar ratio of 16α,17α-cyclohexanopregn-5-en-3β-ol-20-one acetate: p-carbomethoxyperbenzoic acid of 1:1.1-1.5. The end product contained in the solution is easily separated after filtering the p-carbomethoxybenzoic acid precipitate.

EFFECT: safety and simplification of the disclosed method and increase in directivity of the process towards obtaining an -isomer of the end product; invention can be used to produce an intermediate product during synthesis of pregnane steroid hormones which are valuable hormonal agents used in medicine.

2 cl, 4 ex

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RU 2 480 477 C1

Authors

Zavarzin Igor' Viktorovich

Levina Inna Solomonovna

Dates

2013-04-27—Published

2011-12-28—Filed