INTRA-ARTICULAR FLUID SIMULATOR FORMULATION AND METHOD FOR PREPARING INTRA-ARTICULAR FLUID ADDITIVE Russian patent published in 2013 - IPC A61K31/79 A61K31/728 A61K33/38 A61P19/02 B82B1/00 B82Y5/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: declared group of inventions refers to an intra-articular fluid (synovial fluid) simulator formulation, and to a method for preparing an additive to said formulation. The intra-articular fluid simulator formulation contains 15% aqueous medium molecular polyvinyl pyrrolidone, (0.5-1.5)-10^-3 wt % of an additive with the antimicrobial properties and 0.05-2.5% of hyaluronic acid sodium salt in deionised water at the weight relation: of polyvinyl pyrrolidone: hyaluronic acid sodium salt as 1:(0.2-0.3). The additive is prepared of silver modified silicone nanoparticles at nanoparticle size 10-40 nm and silver amount in the additive 0.8-1.1 wt %. The method for preparing the additive to intra-articular fluid simulator formulation consists in preparing silicone nanoparticles by pyrolytic laser processing of monosilane (SiH₄), modifying their surfaces by nanoparticle processing in 2-5% silver nitrate in deionised water and centrifuging the solution, multiply washing the deposition and centrifuging at each washing stage.

EFFECT: group of inventions provides preparing the biologically compatible intra-articular fluid simulator formulation showing the effective rheology, antimicrobial activity, and promoting repair action on cartilaginous tissues.

6 cl, 1 tbl, 1 dwg, 4 ex