FIELD: biotechnology.
SUBSTANCE: invention relates to peptide antagonists of calcitonin gene-associated peptide (CGRP), and can be used in medicine for treating a condition associated with high CGRP, including migraine. Disclosed is a peptide having the structure X1-Y1-Z1, where X1 is a modified N-terminal CGRP fragment containing from 5 to 7 amino acid residues, where 2 amino acids of said N-terminal fragment are cysteine residues (Cys), wherein the C-terminal amino acid residue of the N-terminal fragment is Cys, residue immediately before C-terminal Cys residue of said N-terminal fragment is a substitution of a residue of threonine (Thr) by nethreonine, wherein two cysteine residues are separated by 4, 5 or 6 amino acids and wherein said 2 Cys residues can form a disulphide bond; Y1 is selected from Val-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Thr-Asn, Val-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Val-Asp; and Z1 is selected from Thr-Gly-Ser-Gly-Thr-Pro-NH2, Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 or Val-Gly-Ser-Lys-Ala-Phe-NH2.
EFFECT: invention provides preparing an effective CGRP antagonist.
13 cl, 7 tbl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
PEPTIDE ANTAGONISTS OF PEPTIDE HORMONES FROM THE CALCITONIN GROUP (CALCITONIN GENE-RELATED PEPTIDES (CGRP)) AND THEIR APPLICATION | 2013 |
|
RU2624016C2 |
METHODS AND COMPOSITIONS FOR TREATMENT OF GASTROINTESTINAL DISORDERS | 2014 |
|
RU2763796C2 |
RECOMBINANT VIRAL PARTICLES WITH MODIFIED TROPISM AND WAYS OF THEIR USE FOR TARGETED INTRODUCTION OF GENETIC MATERIAL INTO HUMAN CELLS | 2018 |
|
RU2811426C2 |
SELECTION OF PATIENTS WITH HEADACHE SUSCEPTIBLE TO ANTIBODIES AGAINST CALCITONIN GENE-RELATED PEPTIDE | 2018 |
|
RU2770066C2 |
METHODS AND COMPOSITIONS FOR TREATING GASTROINTESTINAL DISORDERS | 2004 |
|
RU2543350C2 |
METHODS AND COMPOSITIONS FOR GASTROENTERIC UPSET THERAPY | 2004 |
|
RU2353383C2 |
T- CELLS WITH COSTIMULATING CHIMERIC ANTIGEN RECEPTOR TARGETING IL13Rα2 | 2015 |
|
RU2749922C2 |
ANTIBODIES TO PAC1 AND THEIR APPLICATION OPTIONS | 2019 |
|
RU2781553C2 |
ATRIAL NATRIURETIC PEPTIDE GRAFTED ANTIBODIES | 2019 |
|
RU2822433C2 |
ANTIGENIC POLYPEPTIDES BASED ON THE RESPIRATORY SYNCYTIAL VIRUS SEQUENCE | 2019 |
|
RU2807992C2 |
Authors
Dates
2021-02-11—Published
2017-06-06—Filed