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2 476 426

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IPC

C07D213/53(2006-01-01)

C07D213/24(2006-01-01)

(21) (22)

Application

2011148168/04, 2011-11-25

(24)

Start date

2011-11-25

(22)

Actual filing date

2011-11-25

(45)

Published

2013-02-27

(72)

Inventor

Trofimov Boris AleksandrovichAmosova Svetlana ViktorovnaElokhina Valentina NikolaevnaJaroshenko Tat'Jana IsaevnaPotapov Vladimir Alekseevich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Irkutskij Institut Khimii Im. A.E. Favorskogo Sibirskogo Otdelenija Rossijskoj Akademii Nauk

METHOD OF PRODUCING PHARMACOPOEIAL 4-THIOUREIDOIMINOMETHYL PYRIDINIUM PERCHLORATE HAVING HIGH TUBERCULOSTATIC ACTIVITY Russian patent published in 2013 - IPC C07D213/53 C07D213/24

Abstract RU 2476426 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 4-thioureidoiminomethyl pyridinium perchlorate, having high tuberculostatic activity by reacting 4-pyridinoaldehyde, perchloric acid and thiosemicarbazide in an aqueous medium, wherein thiosemicarbazide is added to the obtained 4-pyridine aldehyde perchlorate (concentration of 28-46%) in molar ratio 4-pyridine aldehyde: thiosemicarbazide: perchloric acid of 1:1:1.05. The technical result is a novel simple, practically feasible and ecologically clean single-reactor method of producing pharmacopoeial 4-thioureidoiminomethyl pyridinium perchlorate (PERCHLOZONE^®).

EFFECT: process does not require power consumption, additional heating or cooling.

3 cl, 7 ex

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RU 2 476 426 C1

Authors

Trofimov Boris Aleksandrovich

Amosova Svetlana Viktorovna

Elokhina Valentina Nikolaevna

Jaroshenko Tat'Jana Isaevna

Potapov Vladimir Alekseevich

Dates

2013-02-27—Published

2011-11-25—Filed