METHOD FOR PRODUCING MONO- AND BILIGAND COMPOUNDS OF BIVALENT METAL - ZINC, COPPER (II) AND CALCIUM IONS AND DIHYDROQUERCETIN POSSESSING IMPROVED ANTIOXIDANT ACTIVITY Russian patent published in 2015 - IPC A61K31/352 A61K33/06 A61K33/20 A61K33/34 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for producing a complex compound of dihydroquercetin with metal ions specified in zinc, copper (II) or calcium possessing antioxidant activity. A method consists in the fact that dihydroquercetin and metal salt is mixed in the dry state in a reactor in certain molar ratio; that is followed by adding water at a certain temperature or ethanol or aqueous-alcoholic solution at a room temperature at the controlled medium acidity; using metal salts containing weak acid anions provides medium pH equal to 5.0-5.6; using the metal salts containing strong acid anions requires reducing pH to 7 by adding an alkaline solution; the reaction is completed almost immediately for the first 5 minutes; the precipitation is filtered in water and/or ethanol; dried in air, then in a drying box to constant weight, and a complex compound is produced. The declared method enables reducing the production costs substantially and cheapening the technological process in achieving the target yield with the preset properties.

EFFECT: method enables producing the stable metal structures and individual powdered substances.

3 cl, 3 dwg, 3 tbl, 12 ex