FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of medicine, namely to immunology, and can be applied for induction of immune response in case of stable infection. For this purpose introduced are therapeutically effective quantity of active T-cells, where T-cells specifically recognize antigen of interest, and therapeutically effective quantity of PD-1, thus inducing immune response on antigen of interest, and individual suffers from stable infection by pathogen, and where antigen of interest represents antigen of said pathogen. Also claimed is method of treatment of individual with stable infection by introducing therapeutically effective quantity of antagonist of programmed death (PD-1) peptide and therapeutically effective quantity of antigenic molecule form pathogen.
EFFECT: group of inventions makes it possible to enhance specific immune response by carrying out adoptive therapy with T-cells in combination with PD-1 antagonist.
50 cl, 29 dwg, 25 ex
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