4-HYDROXYBENZOMORPHAN Russian patent published in 2013 - IPC C07D221/26 A61K31/485

Abstract RU 2480455 C2

FIELD: chemistry.

SUBSTANCE: invention relates to 4-hydroxybenzomorphan of formula (I), wherein A is selected from -C(=O)NH₂ and -C(=S)NH₂; R² and R^2a are both a hydrogen atom; R³ is selected from a hydrogen atom, C₃-C₄cycloalkyl, alkenyl, aryl and tetrahydrofuranyl; R⁴ is selected from a hydrogen atom, hydroxy and a lower alkoxy group; R¹¹ is a hydrogen atom; R¹² is selected from a hydrogen atom, hydroxy and lower alkoxy group; or radicals R¹¹ and R¹² together form a carbonyl or vinyl substitute; the dotted line denotes an optional double bond. Compounds of formula (I), wherein A is selected from -C(=O)NH₂ and -C(=S)NH₂; R² and R^2a are both a hydrogen atom; R³ is selected from a hydrogen atom, C₃-C₄cycloalkyl and alkenyl; R⁴ is selected from a hydrogen atom and hydroxy; R¹¹ is a hydrogen atom; R¹² is selected from a hydrogen atom and hydroxy; or radicals R¹¹ and R¹² together form a carbonyl or vinyl substitute; the dotted line denotes an optional double bond, are used to prepare a medicinal agent for treating opioid receptor-mediated diseases or conditions.

EFFECT: obtaining 4-hydroxybenzomorphans, having high affinity for the opioid receptor.

11 cl, 4 tbl, 8 ex

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RU 2 480 455 C2

Authors

Uehntlehnd Mark P.

Dates

2013-04-27—Published

2005-11-03—Filed