TRICYCLIC COMPOUNDS OF BENZOPYRAN AS ANTIARRHYTHMIC AGENTS Russian patent published in 2010 - IPC C07D491/52 C07D491/153 C07D493/04 C07D498/04 C07D515/04 A61K31/436 A61P9/06 

FIELD: chemistry.

SUBSTANCE: invention relates to benzopyran derivatives of formula or

or their pharmaceutically acceptable salts, where R¹ and R² independently represent a hydrogen atom or a C_1-6alkyl group, R³ is a hydroxyl group, R⁴ is a hydrogen atom, m is an integer ranging from 1 to 4, n is an integer ranging from 0 to 4, V is a single bond, CR⁷R⁸ or NR⁹, R⁵ is a hydrogen atom, R⁶ is a hydrogen atom, C_1-6alkyl group, C_3-8cycloalkyl group, C_3-8cycloalkenyl group, amino group, C_1-6alkylamino group, C_6-14aryl group, C_2-9heteroaryl group or C_2-9heterocyclic group, A is a 5- or 6-member ring condensed with a benzene ring, and the ring can contain an oxygen atom, a nitrogen atom or a sulphur atom numbering from 1 to 3 or separately, or combined, the number of unsaturated bonds in the ring equals 1, 2 or 3, including the unsaturated bond in the condensed benzene ring, carbon atoms in the ring can represent carbonyl or thiocarbonyl.

EFFECT: compounds can be used as antiarrhythmic agents.

47 cl, 1 tbl, 98 ex