2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5-HT3 MODULATORS Russian patent published in 2012 - IPC C07D413/14 C07D413/12 C07D453/02 C07D451/04 C07D451/14 C07D453/06 A61K31/423 A61K31/435 A61K31/4523 A61K31/495 A61K31/496 A61K31/497 A61K31/498 A61K31/5377 A61K31/4427 A61K31/541 A61P1/08 A61P3/04 A61P17/04 A61P11/06 A61P25/08 A61P25/30 A61P25/32 A61P1/04 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula where R₁, R₂ and R₃ are independently selected from a group consisting of hydrogen, halogen and lower alkyl containing 1-6 carbon atoms; R₄ denotes a residue given in the claim; R₅ denotes hydrogen or methyl; R₁₀ is selected from a group consisting of: (i) hydrogen; (ii) (C₁-C₁₀) alkyl; (iii) (C₁-C₁₀)alkyl, substituted with one or more substitutes independently selected from a group consisting of -N(CH₃)₂, morpholinyl, (C₁-C₄) alkoxy, hydroxyl, -CON(CH₃)₂ and halogen; (iv) monocyclic (C₃-C₈) cycloalkyl containing one N heteroatom; (v) 9-methyl-9-azabicyclo[3.3.1]nonane; (vi) phenyl; (vii) phenyl substituted with one or more (C₁-C₄)alkoxy; R₁₁ is selected from a group consisting of hydrogen and (C₁-C₁₀)alkyl; or R₁₀, R₁₁ and a nitrogen atom with which they are bonded, together, form a nitric heterocycle or a substituted nitric heterocycle, such as given in the claim. The invention also relates to a pharmaceutical composition, having serotonin type 3 receptor modulating capacity and a method of treating a disorder which depends on serotonin type 3 receptor modulation.

EFFECT: compounds of formula II as serotonin type 3 receptor modulators.

18 cl, 1 tbl, 159 ex