FIELD: chemistry.
SUBSTANCE: in order to reduce content of dimers in a composition which contains a factor VII polypeptide or a version of factor VII polypeptide, pH of said composition is brought to a value ranging from 5 to 10.0; the composition is heated to temperature ranging from 20°C to 50°C for 10 minutes to 72 hours, followed by cooling to temperature not higher than 5°C.
EFFECT: low dimer content in a factor VII polypeptide composition by heat treatment.
8 cl, 4 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CLOSED CONTAINER, CONTAINING ACTIVATED FACTOR VII POLYPEPTIDE METHODS OF OBTAINING IT AND SET AND METHOD OF SET APPLICATION | 2006 |
|
RU2440810C2 |
| LIQUID COMPOSITION OF FACTOR VII POLYPEPTIDES | 2002 |
|
RU2357751C2 |
| STABILISATION OF PROTEIN IN SOLUTION | 2004 |
|
RU2364609C2 |
| LIQUID WATER PHARMACEUTICAL COMPOSITION CONTAINING FACTOR VII POLYPEPTIDE | 2004 |
|
RU2388460C2 |
| METHOD OF REMOVING VIRUSES FROM LIQUID COMPOSITION CONTAINING FACTOR VII | 2004 |
|
RU2472804C2 |
| REDUCING CONTENT OF PROTEIN CONTAMINANTS IN COMPOSITIONS CONTAINING VITAMIN K-DEPENDENT PROTEIN OF INTEREST | 2005 |
|
RU2460735C2 |
| INTEGRAL APPLICATION OF FACTOR VII POLYPEPTIDES AND FACTOR IX POLYPEPTIDES | 2002 |
|
RU2292909C2 |
| COMBINED APPLICATION OF FACTOR VII POLYPEPTIDES AND FACTOR VIII POLYPEPTIDES | 2002 |
|
RU2311923C2 |
| MODIFIED COAGULATION FACTOR VIIa WITH EXTENDED HALF-LIFE | 2007 |
|
RU2466141C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING FACTOR VII POLYPEPTIDES AND FACTOR XI POLYPEPTIDES | 2002 |
|
RU2298416C2 |
