FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a combined antihypertensive drug containing an agent presented by Amlodipine besilate and Lisinopril dehydrate mixed with an excipient. As the excipient, the specified antihypertensive drug contains microcrystalline cellulose of an average particle size of 90-100 mcm and a bulk density of 0.28-0.33 g/ml; as additives, it contains colloidal silicon dioxide, magnesium stearate and sodium carboxymethyl starch. The invention also refers to a method for preparing the mentioned antihypertensive drug by direct compression.
EFFECT: providing a stable drug preparation, more storage-stable, having high producibility, active substance distribution uniformity and bioavailability.
8 cl, 2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMBINED MEDICATION FOR TREATMENT OF ARTERIAL HYPERTENSION IN PATIENTS WITH DIABETES MELLITUS | 2012 |
|
RU2558099C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING DESLORATADINE (VERSIONS) | 2013 |
|
RU2537169C1 |
| STABLE PHARMACEUTICAL PREPARATION CONTAINING AMLODIPINE BENZYLATE AND ATENOLOL | 1998 |
|
RU2188636C2 |
| SOLID MEDICINAL FORM INTENDED FOR TREATMENT OF ARTERIAL HYPERTENSIA AND STENOCARDIA, AND WAY OF ITS RECEPTION | 2008 |
|
RU2359672C1 |
| WATER-DISPERSIBLE DESLORATADINE PILL AND METHOD FOR ITS MANUFACTURE | 2015 |
|
RU2631619C2 |
| COMBINED CONTROLLED-RELEASE PHARMACEUTICAL AGENT CONTAINING DIHYDROPYRIDINE CALCIUM CANAL BLOCKERS AND HMG-CoA-REDUCTASE INHIBITORS | 2007 |
|
RU2450804C2 |
| PROLONGED ANTIHYPERTENSION PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING IT | 2012 |
|
RU2543637C2 |
| ANTIVIRAL AND IMMUNOSTIMULATING DRUG | 2015 |
|
RU2593570C1 |
| TWO-LAYERED TABLET FOR PREVENTING CARDIOVASCULAR DISTURBANCES, DRUG AND METHOD FOR PREVENTING CARDIOVASCULAR DISTURBANCES, INCLUDING APOPLEXY AND PARALYSIS BY USING SAID TABLET | 2007 |
|
RU2445088C2 |
| AGENT BASED ON DRY MOTHERWORT EXTRACT AND METHOD FOR PRODUCTION THEREOF | 2015 |
|
RU2589507C1 |
