FIELD: biotechnologies.
SUBSTANCE: invention discloses a bispecific antibody or its functional fragment, specifically binding with IL-4 and IL-13, which contain variable domains of light and heavy chains with established amino acid sequence. The invention also includes use of antibodies or its functional fragments within a pharmaceutical composition for treatment of diseases or disturbances mediated by IL-4 and/or IL-13, including allergic diseases, asthma, cancer. The invention discloses a molecule of nucleic acid, which codes a bispecific antibody or its fragment, an expression vector and a master cell for production of a bispecific antibody and its functional fragment.
EFFECT: invention makes it possible to produce and use new inhibitors of cytokines, preserving stability in process of production and use in vivo.
17 cl, 2 dwg, 8 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IL-4 AND/OR IL-13 BINDING ANTIBODIES AND USING THEM | 2008 |
|
RU2580049C2 |
| ANTIBODIES BINDING IL-4 AND/OR IL-13, AND THEIR USE | 2015 |
|
RU2721236C2 |
| ANTIBODIES BINDING IL-4 AND/OR IL-13, AND USE THEREOF | 2015 |
|
RU2705551C2 |
| NOVEL ANTI-IL13 ANTIBODIES AND USE THEREOF | 2004 |
|
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| MONOCLONAL ANTIBODY TO IL-5RΑ | 2017 |
|
RU2698048C2 |
| IL-1beta-BINDING ANTIBODIES AND FRAGMENTS THEREOF | 2006 |
|
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| ANTI-IL-22R-ANTIBODIES | 2017 |
|
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| ANTI-IL-6 ANTIBODIES, METHODS AND USING | 2002 |
|
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| IMMUNOTHERAPY OF MALIGNANT DISEASES OF B-CELLS AND AUTOIMMUNE DISEASES WITH APPLICATION OF CONJUGATE AND NONCONJUGATE ANTIBODIES, COMBINATIONS OF ANTIBODIES AND CONJOINT PROTEINS | 2003 |
|
RU2335297C2 |
| IL-1 BINDING PROTEINS | 2011 |
|
RU2615173C2 |
