METHOD FOR PREPARING FINELY DIVIDED IBUPROFEN Russian patent published in 2013 - IPC A61K9/19 A61K31/192 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, particularly to methods for preparing finely divided dosage forms of ibuprofen widely used in medicine. What is presented is a method by quick cooling of the solutions by solution spraying into a liquid nitrogen container; the solvents are removed further by heating wherein an original substance is presented by ibuprofen, and the solvent is a 1,4-dioxane-water and acetone-water system, wherein the range of the ibuprofen concentrations in the original substance is 80-95% of ibuprofen solubility in this mixture of solvents at certain temperature; the water content in the 1,4-dioxane-water system shall not exceed 30 wt %, and that in the acetone-water system is 30-50 wt %; the prepared solid mixture is sublimated by progressive rise of temperature within the range of -196°C to +30°C in a vacuum-processed temperature-controlled container.

EFFECT: developing the method for preparing the finely divided dosage forms of ibuprofen widely used in medicine.

3 cl, 3 ex, 8 dwg