FIELD: chemistry.
SUBSTANCE: as medications composition includes beclomethazone dipropionate and salbutamol, with beta-glycine serving as carrier. Composition is obtained by dispersing solutions of initial medications in mixed solvent into tank with liquid nitrogen with further removal of solvents from obtained by dispersion mixture solid phases in dry nitrogen flow under pressure 600±20 mtorr to pressure drop less than 8 mtorr with stopping nitrogen supply by step-by-step increase of temperature: in the interval from -196°C to -15°C, then from -15°C to +30°C. As initial substances used are: beclomethazone dipropionate 1.9-5.1 wt %, salbutamol 1.9-10.2 wt %, alpha-glycin to 100%. Composition of mixed solvent includes tetrahydrofurane 5-15 wt %, tert-butyl alcohol 15-5 wt %, water 77-80 wt %.
EFFECT: invention provides obtaining highly dispersed pharmaceutical composition of salbutamol and beclomethazone dipropionate.
2 cl, 10 dwg, 3 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HIGHLY DISPERSIVE PHARMACEUTICAL COMPOSITION OF BUDESONIDE WITH BETA-GLYCINE AND METHOD OF OBTAINING THEREOF | 2013 |
|
RU2539376C1 |
| METHOD FOR PREPARING FINE PHARMACEUTICAL COMPOSITIONS OF SALBUTAMOL | 2012 |
|
RU2504370C1 |
| WATER-SOLUBLE COMPOSITION, POSSESSING ANTI-TUMOUR ACTIVITY AND METHOD FOR OBTAINING THEREOF | 2015 |
|
RU2611362C1 |
| DIPROPIONATE BETULIN COMPOSITION | 2013 |
|
RU2541153C1 |
| METHOD FOR PREPARING FINELY DIVIDED IBUPROFEN | 2012 |
|
RU2491919C1 |
| METHOD OF OBTAINING HIGHLY-DISPERSIVE PARACETAMOL | 2010 |
|
RU2449777C1 |
| BETULIN DIACETATE-BASED COMPOSITION | 2013 |
|
RU2517157C1 |
| METHOD OF PRODUCING BETULINOL DIPROPIONATE | 2011 |
|
RU2469043C1 |
| METHOD OF PRODUCING PLATINUM (IV) DIOXIDE ON SUPPORT SURFACE | 2014 |
|
RU2554356C1 |
| METHOD OF PRODUCING BETULINOL DIPROPIONATE | 2015 |
|
RU2579519C1 |
