NEW COMBINATION OF ACTIVE INGREDIENTS CONTAINING NON-STEROID ANTI-INFLAMMATORY DRUG AND COLCHICOSIDE DERIVATIVE Russian patent published in 2013 - IPC A61K31/704 A61K31/192 A61K45/06 A61P19/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to a composition for relieving and/or treating musculoskeletal, articular and juxta-articular diseases, and painful muscle spasm. A pharmaceutical composition for relieving and/or treating musculoskeletal, articular and juxta-articular diseases, and painful muscle spasm, wherein the above composition is presented in the form of a solid dosage form containing a combination of ketoprofen and thiocolchicoside found in the free form or in the form of a salt, in the absence of direct contact in between when mixing the composition. Using the for relieving and/or treating the musculoskeletal and articular diseases, including ankylosing spondylitis, low back pain, osteoarthritis and rheumatoid arthritis, and the juxta-articular diseases, such as bursitis and tendonitis and painful muscle spasm. A method for preparing a tablet dosage form for relieving and/or treating the musculoskeletal, articular and juxta-articular diseases, and painful muscle spasm (versions).

EFFECT: composition is stable and characterised by the low impurity level.

11 cl, 5 ex