FIELD: chemistry.
SUBSTANCE: present invention provides a method of controlling conditions for site-specific binding of a polypeptide and a non-peptide polymer by controlling pH and alcohol content of the reaction medium.
EFFECT: method is intended to prevent formation of secondary conjugates, wherein a non-peptide polymer binds with a physiologically vital amino acid residue.
15 cl, 36 dwg, 25 ex
| Title | Year | Author | Number |
|---|---|---|---|
| INSULINOTROPIC COMPLEX IN WHICH IMMUNOGLOBULIN FRAGMENT IS USED | 2008 |
|
RU2436589C2 |
| CONJUGATE CONTAINING OXINTOMODULIN AND IMMUNOGLOBULIN FRAGMENT, AND ITS APPLICATION | 2012 |
|
RU2733544C2 |
| POLYPEPTIDE COMPLEX CONTAINING NON-PEPTIDYL POLYMER, HAVING THREE FUNCTIONAL ENDS | 2009 |
|
RU2483081C2 |
| COMPOSITION FOR HYPERLIPIDEMIA TREATMENT CONTAINING OXYNTOMODULIN DERIVATIVE | 2013 |
|
RU2642267C2 |
| CONJUGATE, CONTAINING OXYNTOMODULIN AND FRAGMENT OF IMMUNOGLOBULIN, AND USE THEREOF | 2012 |
|
RU2607365C2 |
| COMPOSITION FOR TREATING HYPERLIPIDEMIA CONTAINING AN OXYNTOMODULIN DERIVATIVE | 2013 |
|
RU2768853C1 |
| IMPROVED METHOD FOR PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE PRODUCTION | 2013 |
|
RU2639256C2 |
| COMPOSITION FOR TREATING DIABETES, CONTAINING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE | 2012 |
|
RU2606840C2 |
| METHOD FOR PRODUCING PHYSIOLOGICALLY ACTIVE POLYPEPTIDE COMPLEX | 2012 |
|
RU2624129C2 |
| PHARMACEUTICAL COMPOSITION FOR NON-ALCOHOLIC FATTY LIVER DISEASE PREVENTION OR TREATMENT | 2013 |
|
RU2635966C2 |
