FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine. The agent represents a mixture of peptides of molecular weight 500-900 Da prepared of the brain of cattle and/or pigs of one year old or younger, particularly the midbrain (mesencephalon), namely the central grey substance surrounding the Sylvian aqueduct (aquaeductus cerebri Sylvii) with the peptide mixture concentration in the agent of 5.0-10.0 mg/ml of the aqueous solution or the content of 5.0-10.0 mg/g in a witepsol suppository. The method involves grinding the cattle and/or porcine frozen midbrain, hydrolysis at +20°C in the presence of pepsin, extraction, separation of the extract from ballast substances by separation through materials with retention potential more than 2000 Da, separation of the purified extract by fluid extraction at critical temperature CO2 31.1°C and critical pressure 7.3±0.1 atm, separation of the fraction of 500-900 Da, dissolution in water and freeze drying. The agent is applied in the form of the solution in water in the active substance concentration of 5.0-10.0 mg/ml for single parenteral administration in a dose of 10-30 mg, or in the form of a witepsol suppository with the active substance concentration of 5.0-10.0 mg/ml for single rectal administration in a dose of 10-30 mg.
EFFECT: group of inventions provides higher performance efficiency and tolerance in trained individuals at least by 10-12% as compared with the reference group.
3 cl, 5 ex, 10 tbl, 2 dwg
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Authors
Dates
2013-10-27—Published
2012-03-22—Filed