HYBRID PROTEINS AND PROTEIN CONJUGATES BASED ON HEAT SHOCK PROTEIN-70 (HSP70) AND METHODS FOR USE THEREOF (VERSIONS) Russian patent published in 2019 - IPC C07K14/47 C07K19/00 A61K38/17 A61P43/00 A61K51/08 

FIELD: biotechnology.

SUBSTANCE: invention relates to production of heat proteins based on heat shock protein-70 (HSP70) and their conjugates with radioactive isotopes, and can be used in medicine for treating HSP-dependent disorders or diseases selected from muscular injuries caused by intense physical activity, stroke, hepatic fibrosis, melanoma, as well as to increase performance in intense physical activity. A HSP70-based protein protein consisting of a Fc fragment of human immunoglobulin G1 (IgG1) cross-linked by a peptide linker with a tobacco mosaic virus protease cleavage site to the N-terminus of human HSP70 is obtained. HSP70-Fc hybrid protein can carry a radioactive isotope label ¹²⁴I, ¹²⁵I or ¹³¹I.

EFFECT: invention enables to obtain a prolonged preparation of HSP70 with high ATPase activity.

9 cl, 11 dwg, 13 tbl, 12 ex