SUSTAINED RELEASE PHARMACEUTICAL COMPOSITION IN THE FORM OF A SUPPOSITORY CONTAINING HEXAPEPTIDE Russian patent published in 2020 - IPC A61K9/02 A61K38/08 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to pharmaceutics and is intended for obtain a suppository for rectal administration. To obtain a suppository for rectal administration, a sustained-release pharmaceutical composition containing 0.02–2.0 wt. % hexapeptide of formula H-Tyr-D-Ala-Gly-Phe-Leu-Arg-OH (I) or a pharmaceutically acceptable salt thereof and a suppository base is used. A method for preparing said suppository involves a step for dissolving a hexapeptide of formula (I) or a pharmaceutically acceptable salt thereof in water and a step of mixing the obtained solution with a suppository base to obtain a suppository.

EFFECT: use of group of inventions provides prolonged and proportional release of hexapeptide (I) into blood circulation system, which enables to maintain the therapeutically effective blood hexapeptide (I) levels for a longer period of time than when the hexapeptide (I) is injected in the same dosage.

14 cl, 5 tbl, 5 ex