FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention is aimed at pharmaceutical compositions and methods of producing such compositions, where compositions include combination of particles with synchronised impulse release (SIR-particles) and particles with fast release (FR-particles). Each SIR-particle includes core, covered with SIR-layer; core includes weakly basic poorly soluble medicinal substance and pharmaceutically acceptable organic acid, which are separated from each other by layer with delayed release. Each FR-particle includes granule, which contains weakly basic poorly soluble medicinal substance, pharmaceutically acceptable binding substance, at least, one auxiliary substance and, at least, one backing powder. As organic acid, fumaric acid is preferably applied. FR-granules are conjoined with SIR-granules in single pharmaceutical formula, for example, in capsule.
EFFECT: medical form by invention has improved profile of release of weakly basic poorly soluble medicinal substances and is suitable for oral introduction once per day.
32 cl, 11 dwg, 2 tbl, 8 ex
