VESICLE-CONTAINING COMPOSITION AND METHOD FOR PREPARATION THEREOF Russian patent published in 2014 - IPC A61K8/14 A61K9/127 A61K8/894 A61Q19/00 

Abstract RU 2517710 C1

FIELD: chemistry.

SUBSTANCE: disclosed is a vesicle-containing composition which is characterised by that it contains: (A) a silicone-based surfactant which is silicon modified with polyoxyalkylene, (B) one or more anionic surfactants selected from polyoxyethylenealkyl(12-15)ether-phosphate, acylmethyltaurate and acylglutamate in amount of 0.001-0.2 wt %, (C) polar oil having IOB of 0.05-0.80 and/or silicone oil, and (D) water, which contains a water-soluble medicinal agent, in amount of 0.5-5 wt % of the weight of the composition, where the silicone-based surfactant (A) forms vesicles; the anionic surfactant(s) (B) is attached to the surface of the vesicles; and the polar oil and/or silicone oil (C) is present inside the bilayer membrane of the vesicles.

EFFECT: disclosed composition has excellent stability even in the presence of high concentrations of a water-soluble medicinal agent.

6 cl, 8 tbl, 10 ex

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RU 2 517 710 C1

Authors

Nisida Mikharu

Vatanabe Kei

Matsusita Judzi

Dates

2014-05-27Published

2011-03-25Filed