METHOD OF OBTAINING DERIVATIVES OF 2-DIALKYLAMINOPYRROLO[1,2-ALPHA][1,4]BENZODIAZEPINE Russian patent published in 2014 - IPC C07D487/04 

FIELD: chemistry.

SUBSTANCE: invention relates to synthesis of heterocyclic compounds - derivatives of 2-dialkylaminopyrrolo[1,2-alpha][1,4]benzodiazepine of general formula I where 1a R₁=OMe, R₂=morpholin-4-yl; 1b R₁=H, R₂=morpholin-4-yl; 1c R₁=H, R₂=piperidin -1-yl; 1d R₁=OMe, R₂=pyperidin -1-yl; 1e R₁=H, R₂=diethylamino; 1f R₁=OMe, R₂=diethylamino. Method of obtaining derivatives of 2-dialkylaminomethylpyrrolo[1,2-alpha][1,4]benzodiazepine of general formula I consists in introduction of dialkylaminomethyl group in β-position of pyrrole ring of pyrrolo[1,2-alpha][1,4]benzodiazepine derivatives as a result of aminomethylation by Mannich of derivatives of pyrrolo[1,2-a][1,4]diazepine, reaction is carried out with boining said compounds in acetohitryl for 4-10 hours with addition of mixture of formalin, acetic acid and secondary amine (4,2 mmol : 17.4 mmole : 1,2 mmole) per 1 mmole of pyrrolo[1,2-alpha][1,4]diazepine.

EFFECT: elaborated is method of obtaining novel compounds, which can be applied as biologically active substances and semiproducts for synthesis of novel heterocyclic systems.

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