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2 524 428

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IPC

C07K7/06(2006-01-01)

A61K38/08(2006-01-01)

A61K8/44(2006-01-01)

(21) (22)

Application

2013102410/10, 2013-01-21

(24)

Start date

2013-01-21

(22)

Actual filing date

2013-01-21

(45)

Published

2014-07-27

(72)

Inventor

Utkin Jurij NikolaevichZhmak Maksim NurgajanovichAndreeva Tat'Jana ViktorovnaKudrjavtsev Denis SergeevichKrjukova Elena ViktorovnaTsetlin Viktor IonovichKasheverov Igor' Evgen'EvichStarkov Vladislav Gennad'EvichShelukhina Irina Valer'Evna

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju

PEPTIDES AND THEIR DERIVATIVES WHICH INTERACT WITH NICOTINIC ACETYLCHOLINE RECEPTOR AND SUITABLE FOR USE IN COSMETOLOGY AGAINST MIMIC AND AGE-RELATED WRINKLES Russian patent published in 2014 - IPC C07K7/06 A61K38/08 A61K8/44

Abstract RU 2524428 C1

FIELD: biotechnology.

SUBSTANCE: compounds have the general formula: X1-X2-X3-Pro-X4-Pro-X5, where X1 is selected from H, Ac-, Palm-; X2 is selected from Trp, Tyr; X3 is selected from Trp, Tyr; X4 is selected from Lys, Orn, Dbu, Dpr, Arg; X5 is selected from-OH, -NH₂, -OCH₃, -OC₂H₅, -NH-C₆H₅. This compound can be represented in the form of retroisomer.

EFFECT: invention enables to block selectively the muscle nicotinic acetylcholine receptor with high efficiency.

12 cl, 7 dwg, 1 tbl, 5 ex

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RU 2 524 428 C1

Authors

Utkin Jurij Nikolaevich

Zhmak Maksim Nurgajanovich

Andreeva Tat'Jana Viktorovna

Kudrjavtsev Denis Sergeevich

Krjukova Elena Viktorovna

Tsetlin Viktor Ionovich

Kasheverov Igor' Evgen'Evich

Starkov Vladislav Gennad'Evich

Shelukhina Irina Valer'Evna

Dates

2014-07-27—Published

2013-01-21—Filed