PHARMACEUTICAL COMPOSITION IN FORM OF SOLUTION FOR INJECTION AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2014 - IPC A61K9/08 A61K31/4015 A61K47/36 A61P25/28 

Abstract RU 2524651 C1

FIELD: chemistry.

SUBSTANCE: invention discloses a pharmaceutical composition in the form of a solution, having nootropic and neuromodulating activity, characterised by that it contains N-carbamoylmethyl-4-phenyl-2-pyrrolidone as an agent, hydroxyethyl starch as an auxiliary substance and water for injection. The invention also relates to a method of producing such a pharmaceutical composition, which includes adding hydroxyethyl starch to the water for injection which is preheated to 85-90°C and mixing until complete dissolution, adding N-carbamoylmethyl-4-phenyl-2-pyrrolidone powder and mixing at temperature of 75-85°C until complete dissolution, adding water for injection to obtain the end volume of the solution and mixing once more, holding the obtained solution for 35-40 minutes at temperature of 75-85°C, cooling to 20-30°C, sterilising by filtering through filters with pore diameter of 0.22 mcm and packing in ampoules, which are further sterilised for 8 minutes at temperature of 120°C.

EFFECT: composition is effective, safe and can be used for a long period of time.

2 cl, 3 ex

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RU 2 524 651 C1

Authors

Kul'Kin Sergej Nikolaevich

Dates

2014-07-27Published

2013-06-20Filed