TOM34 GENE RELATED TO COLON CANCER Russian patent published in 2014 - IPC G01N33/574 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for inducing antitumour immunity by contacting an antigen-presenting cell with an immunologically active fragment specified in a group consisting of: (i) an immunologically active fragment of a polypeptide coded by nucleic acid of TOM34 presenting a decapeptide possessing an ability to induce cytotoxic T-cells containing an amino acid sequence SEQ ID NO:7; (ii) an immunologically active fragment of a polypeptide coded by nucleic acid of TOM34 presenting a peptide possessing an ability to induce cytotoxic T-cells, wherein the peptide contains amino acid sequence SEQ ID NO:7, wherein 1 or 2 amino acids are substituted or added; (iii) an immunologically active fragment (ii), wherein the second amino acid from N terminal of the amino acid sequence SEQ ID NO:7 represents phenylalanine, tyrosine, methionine or tryptophan; and (iv) an immunologically active fragment (ii), wherein C-terminal amino acid of the amino acid sequence SEQ ID NO:7 represents phenylalanine, leucine, isoleucine, tryptophan or methionine, or with a polynucleotide coding the above fragment, or with a vector containing the above polynucleotide.

EFFECT: using the invention provides effective immune therapy of cancer.

10 dwg, 3 tbl