MATRIX TABLET WITH BASIS FOR TRIMETAZIDINE DIHYDROCHLORIDE RELEASE, WAY OF ITS RECEPTION AND WAY OF TREATMENT Russian patent published in 2009 - IPC A61K9/22 A61K31/495 A61P9/10 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention concerns a matrix tablet with a basis for the prolonged trimetazidine or its pharmaceutically comprehensible salt release, (rather, trimetazidine dihydrochloride), possessing membrane stabilising, cytoprotective, antihypoxant and antioxidatic activity containing the combination of hydroxypropyl cellulose and copovidone, at their quantitative parity 20.0-24.7 wt % and 1.3-8.0 wt % in quality of a matrix forming component, way of its reception, way of treatment or prevention of conditions at which introduction of antioxidants is necessary, antihypoxants, cytoprotectors and membrane stabilisers. The offered invention provides optimum quantitative and qualitative structure of components for manufacturing of solid peroral medicinal forms of trimetazidine or its pharmaceutically comprehensible salt of the prolonged action, not rendering allergenic and toxic action, providing gradual and prolonged liberation of the agent during the long period of time.

EFFECT: stable maintenance of effective concentration of trimetazidine in a blood plasma throughout the long period of time.

16 cl, 1 ex, 1 tbl, 1 dwg