MULTISPECIFIC ANTIGEN-BINDING MOLECULE, POSSESSING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII Russian patent published in 2014 - IPC C07K16/36 C07K16/46 C12N15/13 C12N15/63 C12N5/10 A61K39/395 A61P7/04 

Abstract RU 2534347 C1

FIELD: chemistry.

SUBSTANCE: claimed is bispecific antibody, which is bound with both blood coagulation factor IX/activated blood coagulation factor IX and with blood coagulation factor X and functionally replaced function of blood coagulation factor VIII. Described are nucleic acid, coding antibody by invention, vector, cell and method of obtaining antibody, as well as pharmaceutical composition and set for application in method of prevention and/or treatment of bleeding or diseases, associated with or induced by bleeding.

EFFECT: invention can be applied in therapy of diseases, associated with blood coagulation disorders.

16 cl, 2 ex, 6 dwg

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RU 2 534 347 C1

Authors

Igava Tomojuki

Sampehj Zendzhiro

Kodzhima Tetsuo

Soeda Tetsukhiro

Muto Atsushi

Kitazava Takekhiza

Nishida Jukiko

Imai Chifumi

Suzuki Tsukasa

Joshikhashi Kazutaka

Dates

2014-11-27Published

2013-07-04Filed