FIELD: biotechnology.
SUBSTANCE: invention relates to a bispecific antibody that binds to both blood coagulation factor IX/activated blood coagulation factor IX, and blood coagulation factor X, and functionally replaces blood coagulation factor VIII. This invention discloses the nucleic acid encoding the said bispecific antibody, a vector, a cell and a method for antibody production, as well as a pharmaceutical composition and a kit for use in the method for prevention and/or treatment of bleeding or diseases associated with or caused by bleeding.
EFFECT: invention may find further application for treatment of diseases associated with impaired blood clotting, such as acquired hemophilia and von Willebrand disease.
17 cl, 6 dwg, 2 ex
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