METHOD FOR CORRECTION OF REMOTE CONSEQUENCES OF SPERMATOGENESIS CAUSED BY CYTOSTATIC EXPOSURE Russian patent published in 2014 - IPC A61K38/18 A61K47/48 A61P15/08 

Abstract RU 2535002 C2

FIELD: medicine.

SUBSTANCE: what is presented is using a conjugate of a granulocytic colony-stimulating factor immobilised on low-molecular polyethylene glycol prepared by electron-beam synthesis nanotechnology - the exposure to an accelerated electron flow at an energy of 2.5 MeV, absorbed dose 2-10 kGy and collection rate 1.65 kGy/h as agents for the correction of remote consequences of spermatogenesis caused by the cytostatic exposure.

EFFECT: due to the penetration through the blood-testis barrier, the agent corrects disturbed spermatogenesis caused by the cytostatic exposure by the early stimulation of reticular regeneration processes in the testicular tissues in the whole and rapid spermatogonium population recovery; the agent is almost non-toxic.

3 tbl

Similar patents RU2535002C2

Title Year Author Number
REMEDY FOR DELAYED EFFECTS OF SPERMATOGENESIS DISORDERS CAUSED BY CYTOSTATIC EFFECT 2019
  • Borovskaya Tatyana Gennadevna
  • Grigoreva Valeriya Aleksandrovna
  • Vychuzhanina Anna Vladimirovna
  • Poluektova Marina Evgenevna
  • Shchemerova Yulya Aleksandrovna
  • Kamalova Svetlana Ivanovna
  • Dygaj Aleksandr Mikhajlovich
  • Kuchin Aleksandr Vasilevich
  • Chukicheva Irina Yurevna
  • Buravlev Evgenij Vladimirovich
  • Kollantaj Olesya Vadimovna
RU2717240C1
METHOD OF CORRECTING, CAUSED BY CYTOSTATIC IMPACT 2009
  • Borovskaja Tat'Jana Gennad'Evna
  • Dygaj Aleksandr Mikhajlovich
  • Zhdanov Vadim Vadimovich
  • Rumpel' Olesja Aleksandrovna
  • Pakhomova Angelina Vladimirovna
  • Perova Anna Vladimirovna
  • Zjuz'Kov Gleb Nikolaevich
  • Gol'Dberg Viktor Evgen'Evich
RU2406527C1
USE OF COMPLEX OF 9-PHENYL-2,3,4,5,6,7,8,9-OCTAHYDRO-1H-SELENOXANTHENE WITH β-CYCLODEXTRIN FOR CORRECTION OF SPERMATOGENESIS DISORDERS CAUSED BY CYTOTOXIC EFFECT 2019
  • Erimbetov Kenes Tagaevich
  • Bondarenko Ekaterina Valerevna
  • Goncharova Anna Iakovlevna
  • Roziev Rakhimdzhan Akhmetdzhanovich
RU2782758C2
STIMULATOR OF REPARATIVE REGENERATION PROCESSES OF TESTICULAR TISSUE 2019
  • Erimbetov Kenes Tagaevich
  • Bondarenko Ekaterina Valerevna
  • Goncharova Anna Iakovlevna
  • Roziev Rakhimdzhan Akhmetdzhanovich
RU2778238C2
USE OF PHARMACEUTICAL COMPOSITION OF β-CYCLODEXTRIN WITH 9-PHENYL-2,3,4,5,6,7,8,9-OCTAHYDRO-1H-SELENOXANTHENE FOR INCREASING/RESTORING LIBIDO 2019
  • Erimbetov Kenes Tagaevich
  • Bondarenko Ekaterina Valerevna
  • Goncharova Anna Iakovlevna
  • Roziev Rakhimdzhan Akhmetdzhanovich
RU2782133C2
USE OF COMPLEX OF 9-PHENYL-2,3,4,5,6,7,8,9-OCTAHYDRO-1H-SELENOXANTHENE WITH β-CYCLODEXTRIN FOR TREATMENT OF PATHOZOOSPERMIA 2019
  • Erimbetov Kenes Tagaevich
  • Bondarenko Ekaterina Valerevna
  • Goncharova Anna Iakovlevna
  • Roziev Rakhimdzhan Akhmetdzhanovich
RU2782140C2
BISAMIDE DERIVATIVE OF DICARBOXYLIC ACID AS AGENT FOR STIMULATING TISSUE REGENERATION AND RECOVERY OF DIMINISHED TISSUE FUNCTION 2015
  • Nebolsin Vladimir Evgenevich
  • Rydlovskaya Anastasiya Vladimirovna
  • Dygaj Aleksandr Mikhajlovich
  • Borovskaya Tatyana Gennadevna
RU2647438C2
BISAMIDE DERIVATIVE OF DICARBOXYLIC ACID AS AGENT STIMULATING TISSUE REGENERATION AND RESTORATION OF REDUCED FUNCTIONS OF TISSUES 2016
  • Nebolsin Vladimir Evgenevich
  • Rydlovskaya Anastasiya Vladimirovna
  • Dygaj Aleksandr Mikhajlovich
  • Borovskaya Tatyana Gennadevna
  • Skurikhin Evgenij Germanovich
RU2727142C2
MEANS FOR PREVENTING AND CORRECTING SPERMATOGENESIS DISORDERS CAUSED BY CYTOSTATIC TREATMENT 2006
  • Gol'Dberg Evgenij Danilovich
  • Borovskaja Tat'Jana Gennad'Evna
  • Shchemerova Julija Aleksandrovna
  • Timina Evgenija Anatol'Evna
  • Pakhomova Angelina Vladimirovna
  • Perova Anna Vladimirovna
RU2318529C1
METHOD FOR STIMULATION OF SPERMATOGENESIS 2016
  • Tkachuk Vsevolod Arsenevich
  • Akopyan Zhanna Alekseevna
  • Efimenko Anastasiya Yurevna
  • Kamalov Armais Albertovich
  • Kirpatovskij Vladimir Igorevich
  • Makarevich Olga Aleksandrovna
  • Makarevich Pavel Igorevich
  • Nimiritskij Petr Petrovich
  • Okhobotov Dmitrij Aleksandrovich
  • Sagaradze Georgij Dmitrievich
  • Tarasova Elena Vladimirovna
RU2653779C1

RU 2 535 002 C2

Authors

Artamonov Andrej Vladimirovich

Bekarev Andrej Aleksandrovich

Borovskaja Tat'Jana Gennad'Evna

Dygaj Aleksandr Mikhajlovich

Zhdanov Vadim Vadimovich

Zjuz'Kov Gleb Nikolaevich

Madonov Pavel Gennad'Evich

Poluehktova Marina Evgen'Evna

Shchemerova Julija Aleksandrovna

Vychuzhanina Anna Vladimirovna

Dates

2014-12-10Published

2013-04-04Filed