FIELD: medicine.
SUBSTANCE: single-step testing of white rats is carried out in an open field facility. The total length of locomotion, sniffing, and sitting actions as well as the number of upright postures and freezing acts are recorded. Prognostic coefficients F1 and F2 are determined by formulas and compared. If F2 is more than F1, cognitive disorders are stated in experimental animals, and if F1 is more than F2, the above are stated to be absent. That is followed by calculating a prognostic index (PI), which is used to determine an intensity of the cognitive disorders: low, moderate and high.
EFFECT: method enables detecting the presence of the cognitive disorders in the rats by using the values of motor and investigatory activity and anxiety.
2 cl, 2 tbl, 4 ex
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Authors
Dates
2014-12-10—Published
2013-08-01—Filed