FIELD: medicine.
SUBSTANCE: as active ingredients, a formulation contains fenoterol hydrobromide and ipratropium bromide monohydrate; the excipients are absolute ethanol, triethylcitrate, propellant 1,1,1,4 tetrafluoroethane (HFA-134a) and/or 1,1,1,2,3,3,3-heptafluoropropane (HFA-227ea) and a pharmaceutically acceptable acid specified in hydrochloric, orthophosphoric and citric acids.
EFFECT: increasing the respirable fraction and obtaining an optimised particle release profile.
2 dwg, 6 ex
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Authors
Dates
2014-12-20—Published
2013-10-09—Filed