PHARMACEUTICAL AEROSOL COMPOSITION Russian patent published in 2015 - IPC A61K9/12 A61K47/48 A61K31/00 A61K31/137 A61K31/46 A61P11/00 A61M15/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the chemical-pharmaceutical industry and represents a pharmaceutical aerosol composition, which contains at least one hydrofluoroalkane-based propellant; at least one active substance forming a complex with an adjuvant; and, optionally, one or more pharmaceutically acceptable excipients, where the adjuvant represents polyvinylpyrrolidone in an amount from 0.5% to 100% by the active substance weight, where the active substance is selected from tiotropium, ipratropium, aclidinium, atropine or oxitropium, and where the active substance is subjected to complex formation with the adjuvant by means of a method, including the dissolution of the active substance and adjuvant in the weight ratio of active component:polyvinylpyrrolidone equal 2:1 in a solvent with obtaining a solution and removal of the solvent from the solution under vacuum with obtaining at least one active substance, which formed the complex with the adjuvant.

EFFECT: invention provides an improvement of the aerosol composition stability.

15 cl, 17 tbl