THIOPHENE DERIVATIVES Russian patent published in 2014 - IPC C07D495/04 A61K31/407 A61K31/5377 A61P29/00 A61P31/00 A61P35/00 A61P37/00 

Abstract RU 2536865 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula wherein each of R1 and R2 is independently selected from a group consisting of a hydrogen atom, nitro and NR6R7; R3 is C1-C8alkyl; each of R4 and R5 is independently selected from a group consisting of C1-C8alkoxy, phenoxy and phenyl(C1-C8alkylene)oxy; each of R6 and R7 is independently selected from a group consisting of a hydrogen atom, C1-C8alkyl, C(O)R8 and SO2R8;R8 is selected from a group consisting of a hydrogen atom, C1-C8alkyl, halogen-substituted C1-C8-alkyl, C1-C8-alkyl, substituted (C1-C8-alkylsubstituted amino), C1-C8-alkyl, substituted with piperidine and C1-C8-alkyl, substituted with morpholine.

EFFECT: reduced PDE4 enzyme activity and treating PDE4 enzyme mediated diseases or conditions.

21 cl, 2 tbl, 32 ex

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RU 2 536 865 C2

Authors

Chzhan Khehshehn

Tszehn Guankhuaj

Gao Ifehj

Dates

2014-12-27Published

2010-05-14Filed