FIELD: chemistry.
SUBSTANCE: invention relates to compounds modulating protein function for the purpose of restoring protein homeostasis, including the activity of cytokines, CK1α, GSPT1, aiolos and/or ikaros, as well as intercellular adhesion. Proposed in the present invention are methods for modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Proposed are compositions, including those in combination with other cytokines and inflammation mediators.
EFFECT: ensured modulation of protein-mediated diseases.
39 cl, 11 dwg, 8 tbl, 65 ex
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