METHODS OF OBTAINING CELLS, DEMONSTRATING PHENOTYPIC PLASTICITY Russian patent published in 2014 - IPC C12N5/16 

FIELD: chemistry.

SUBSTANCE: invention relates to molecular biology and cell technologies. Claimed is a method of obtaining a cell with the specified phenotype, where the said method includes stages of hybridisation of the first stem cell or the cell, derived from an uncommitted precursor cell, the second cell, derived from the common lymphoid precursor cell, and the third cell, derived from the common lymphoid precursor cell, with obtaining a hybrid cell, which demonstrates phenotypic plasticity, and influence on the said hybrid cell of conditions, selected from the group, consisting of the thymic stromal cell, cytokine, growth factor, immunoglobulin, ligand of receptors or their combination, in such a way that the said hybrid cell becomes the said cell with the phenotype of B-cell, T-cell, myeloid cell or dedifferentiated phenotype relative to the said hybrid cell.

EFFECT: due to the increase of functional stability of the hybrid cells and increase of their phenotypic plasticity and effectiveness of transdifferentiation, the invention can be used for tissue formation in medicine.

37 cl, 33 dwg, 11 tbl, 7 ex