COMPOSITIONS AND METHODS FOR BOOSTING THE EFFECTIVENESS OF ADOPTIVE CELL IMMUNOTHERAPY Russian patent published in 2020 - IPC A61K38/20 A61K39/00 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a method for improving adoptive cell immunotherapy, comprising (a) administering to an individual an effective amount of a population of modified human T-cells comprising a nucleic acid molecule which codes an exogenous antigen-binding protein, wherein said antigen-binding protein comprises a hydrophobic portion located between the extracellular binding component and the intracellular effector component; and (b) administering to an individual an effective amount of a population of modified haemopoetic human progenitor cells, modified human immune system cells or a combination thereof, comprising a nucleic acid molecule which codes said antigen. Group of inventions also relates to a method of treating a disease associated with antigen expression in a subject, comprising steps of providing an improved adoptive cell immunotherapy; adoptive cell immunotherapy composition, containing (i) a population of modified human T-cells and (ii) a population of modified haemopoetic human progenitor cells, modified human immune system cells or a combination of said cells.

EFFECT: group of inventions provides higher effectiveness of adoptive cell immunotherapy.

74 cl, 5 dwg, 3 ex